The Jeremy Kyle Show has been axed by ITV after the death of a guest who took part in the programme.
Steve Dymond was found dead on 9 May a week after filming the show, during which he took a lie detector test, writes BBC.
ITV's chief executive Carolyn McCall said the decision was a result of the "gravity of recent events".
The channel had initially suspended filming of the show, which had been on the air for more than 3,000 episodes since it began in 2005.
On Tuesday, the prime minister's spokesman called Mr Dymond's death "deeply concerning".
ITV's statement in full:
"Given the gravity of recent events we have decided to end production of The Jeremy Kyle Show.
"The Jeremy Kyle Show has had a loyal audience and has been made by a dedicated production team for 14 years, but now is the right time for the show to end.
"Everyone at ITV's thoughts and sympathies are with the family and friends of Steve Dymond.
"The previously announced review of the episode of the show is under way and will continue.
"ITV will continue to work with Jeremy Kyle on other projects."
The Jeremy Kyle Show was the most popular programme in ITV's daytime schedule, with an average of one million viewers and a 22% audience share.
The pre-recorded episode Mr Dymond took part in was based on the subject of infidelity.
A member of the audience who was at the recording told BBC News that Mr Dymond "collapsed to the ground" and was "sobbing" when he failed the lie detector test.
Lie detectors were a regular fixture on the programme, which often featured disputes between partners and family members.
Critics said it put vulnerable people, often with issues of addiction and mental health, on a public platform - bringing them a level of exposure they may not have expected.
After Mr Dymond's death, ITV took all planned episodes off the air, adding that the episode featuring Mr Dymond would never be screened.
TV critic Emma Bullimore told BBC 5 Live she was surprised by the speed of the decision.
"Usually these things take a review, and it's ages, but with this one the public opinion and the pressure they were under was so strong that they didn't really have another option," she said.
ITV has said it will still work with the host, who also fronts The Kyle Files.
"I don't think this is the end of this kind of television," Bullimore added. "The voices we're hearing are the people who have always disliked the Jeremy Kyle show, always found it exploitative, and are saying, 'We told you something like this was going to happen.'
"There's no getting away from the fact that whether you like it or you find it reprehensible, there is a loyal audience for this show."